![]() Current Topics in Developmental Biology 2020. Logical modeling of cell fate specification-Application to T cell commitment. Distinct Notch1 and BCL11B requirements mediate human γδ/αβ T cell development. ĭolens AC, Durinck K, Lavaert M, Van der Meulen J, Velghe I, De Medts J, Weening K, Roels J, De Mulder K, Volders PJ, De Preter K, Kerre T, Vandekerckhove B, Leclercq G, Vandesompele J, Mestdagh P, Van Vlierberghe P, Speleman F, Taghon T. Single cell profiling of immature human postnatal thymocytes resolves the complexity of intra-thymic lineage differentiation and thymus seeding precursors. Lavaert M, Liang KL, Vandamme N, Park J, Roels J, Kowalczyk MS, Li B, Ashenberg O, Tabaka M, Dionne D, Tickle TL, Slyper M, Rozenblatt-rosen O, Vandekerckhove B, Leclercq G, Regev A, Van Vlierberghe P, Guilliams M, Teichmann SA, Saeys Y, Taghon T. Integrated scRNA-Seq Identifies Human Postnatal Thymus Seeding Progenitors and Regulatory Dynamics of Differentiating Immature Thymocytes. Lavaert M, Liang KL, Vandamme N, Park JE, Roels J, Kowalczyk MS, Li B, Ashenberg O, Tabaka M, Dionne D, Tickle TL, Slyper M, Rozenblatt-Rosen O, Vandekerckhove B, Leclercq G, Regev A, Van Vlierberghe P, Guilliams M, Teichmann SA, Saeys Y, Taghon T. Notch signaling at the crossroads of innate and adaptive immunity. Development of a Notch pathway assay and quantification of functional Notch pathway activity in T-cell acute lymphoblastic leukemia. Ĭanté-barrett K, Holtzer L, van Ooijen H, Hagelaar R, Cordo V, Verhaegh W, van de Stolpe A, Meijerink JP. Distinct and temporary-restricted epigenetic mechanisms regulate human αβ and γδ T cell development. Roels J, Kuchmiy A, De Decker M, Strubbe S, Lavaert M, Liang KL, Leclercq G, Vandekerckhove B, Van Nieuwerburgh F, Van Vlierberghe P, Taghon T. A Molecular Test for Quantifying Functional Notch Signaling Pathway Activity in Human Cancer. Ĭanté-Barrett K, Holtzer L, van Ooijen H, Hagelaar R, Cordo' V, Verhaegh W, van de Stolpe A, Meijerink JPP. The human fetal thymus generates invariant effector γδ T cells. Tieppo P, Papadopoulou M, Gatti D, McGovern N, Chan JKY, Gosselin F, Goetgeluk G, Weening K, Ma L, Dauby N, Cogan A, Donner C, Ginhoux F, Vandekerckhove B, Vermijlen D. PHF6 Expression Levels Impact Human Hematopoietic Stem Cell Differentiation. Loontiens S, Dolens AC, Strubbe S, Van de Walle I, Moore FE, Depestel L, Vanhauwaert S, Matthijssens F, Langenau DM, Speleman F, Van Vlierberghe P, Durinck K, Taghon T. Role of Notch Receptors in Hematologic Malignancies. Gragnani L, Lorini S, Marri S, Zignego AL. Single-cell insights into the hematopoietic generation of T-lymphocyte precursors in mouse and human. Inflammatory Cytokines Regulate T-Cell Development from Blood Progenitor Cells in a Stage and Dose-Specifc Manner. Biological Significance of NOTCH Signaling Strength. Multi-objective optimization reveals time- and dose-dependent inflammatory cytokine-mediated regulation of human stem cell derived T-cell development. Abrogation of Notch Signaling in Embryonic TECs Impacts Postnatal mTEC Homeostasis and Thymic Involution. García-León MJ, Mosquera M, Cela C, Alcain J, Zuklys S, Holländer G, Toribio ML. Generation of T-cell-receptor-negative CD8αβ-positive CAR T cells from T-cell-derived induced pluripotent stem cells. ![]() Van der Stegen SJC, Lindenbergh PL, Petrovic RM, Xie H, Diop MP, Alexeeva V, Shi Y, Mansilla-Soto J, Hamieh M, Eyquem J, Cabriolu A, Wang X, Abujarour R, Lee T, Clarke R, Valamehr B, Themeli M, Riviere I, Sadelain M. Development of γδ T cells in the thymus - A human perspective. Transcriptional regulation of Notch1 by nuclear factor-κB during T cell activation. Hwang JR, Kim D, Kang JA, Park SH, Park SG. Intrathymic dendritic cell-biased precursors promote human T cell lineage specification through IRF8-driven transmembrane TNF. Liang KL, Roels J, Lavaert M, Putteman T, Boehme L, Tilleman L, Velghe I, Pegoretti V, Van de Walle I, Sontag S, Vandewalle J, Vandekerckhove B, Leclercq G, Van Vlierberghe P, Libert C, Van Nieuwerburgh F, Fischer R, Kontermann RE, Pfizenmaier K, Doody G, Zenke M, Taghon T. An early decrease in Notch activation is required for human TCR-alphabeta lineage differentiation at the expense of TCR-gammadelta T cells. Van de Walle I, De Smet G, De Smedt M, Vandekerckhove B, Leclercq G, Plum J, Taghon T.
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